TARDBP as a regulator of HIV-1 assembly and infection: a review of targeting the viral capsid precursor Pr55Gag and limiting viral core entry - PubMed
4 hours ago
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- #HIV-1
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- TARDBP (TDP-43) plays a significant role in combating HIV-1 by targeting viral components.
- TARDBP collaborates with HDAC6 to degrade HIV-1 Pr55Gag and Vif via autophagy, preventing proper virus assembly.
- TARDBP disrupts HIV-1 entry by affecting microtubules, hindering viral core release into host cells.
- The protein's actions complement other antiviral factors and drugs like lenacapavir, targeting the viral capsid.
- Boosting TARDBP activity alongside capsid-targeting drugs could combat drug-resistant HIV-1 and reduce viral reservoirs.