Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity - PubMed
2 hours ago
- #myocardial ischemia-reperfusion
- #ALDH2
- #E3 ubiquitin ligase
- Ubiquitinome analysis shows protein ubiquitination worsens endothelial dysfunction after myocardial I/R injury.
- E3 ubiquitin ligase Hrd1 is upregulated in CD45+ endothelial cells during I/R injury.
- Hrd1 deficiency reduces myocardial infarction, endothelial dysfunction, and inflammation post-I/R.
- Hrd1 promotes K33-linked ubiquitination of ALDH2, inhibiting its active tetramers and NO signaling.
- Pharmacological inhibition of Hrd1 improves myocardial I/R injury and endothelial dysfunction.