A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma - PubMed
4 hours ago
- #melanoma
- #immunosuppression
- #spatial_omics
- A longitudinal, multi-omic atlas of resistant melanoma reveals a shared immunosuppressive ecosystem emerging through convergent evolution.
- Spatial partitioning of immune checkpoints is identified, with B7-H3 in MITF-high niches and IDO1 in MITF-low zones.
- A malignant subclone (c1) and niche (RCN3) show aberrant PI3K-mTOR signaling, promoting an 'ignored tumor' phenotype via FN1-ITGB1 and GDF15 signaling.
- Spatial and molecular signatures predict poor survival and suggest actionable targets for personalized therapy in melanoma resistance.