Evaluating the potential for sperm DNA fragmentation testing to guide the use of ICSI for couples with non-severe male infertility - PubMed
4 hours ago
- #male infertility
- #ICSI vs IVF
- #sperm DNA fragmentation
- Study evaluates sperm DNA fragmentation index (DFI) testing for guiding ICSI vs. IVF in non-severe male infertility.
- Secondary analysis of an RCT shows DFI testing has limited value in identifying couples benefiting from ICSI over IVF.
- No significant differences in cumulative live birth rates between ICSI and IVF across DFI quantiles.
- Multivariable analysis found no interaction between sperm DFI and treatment effect of ICSI over IVF.
- Limitations include non-routine DFI testing across sites and potential underpowering for certain outcomes.
- Suggests DFI testing should not be routinely recommended for non-severe male infertility cases.
- Funded by National Key Research and Development Program and Peking University Third Hospital.