Triple-Cascade Responsive Pneumatic Nanomotor Enhance Cancer Immunotherapy by Oncolytic Virus-Triggered Pyroptosis - PubMed
4 hours ago
- #nanomotor
- #oncolytic virus
- #pyroptosis
- Intravenous delivery of oncolytic viruses (OVs) faces challenges like rapid clearance and poor tumor penetration.
- A triple-cascade responsive pneumatic nanomotor (HLNO) is developed for systemic delivery of oncolytic herpes simplex virus (oHSV).
- HLNO features a core-shell design with oHSV core, glutathione-responsive liposome, and hyaluronic acid outer shell.
- The system enables immune evasion and programmable activation in response to tumor microenvironment stimuli.
- NO-propelled active motion enhances extravasation and deep tissue penetration under acidic conditions.
- HLNO activates the caspase-3/GSDME pathway to induce immunogenic pyroptosis, boosting antitumor immunity.
- The platform enhances immunotherapy efficacy in immunologically 'cold' tumors by integrating immune shielding and cascade-responsive release.