Therapeutic translation of traditional Chinese medicine Huangqi derived exosome like nanoparticles: targeting prostate cancer through ferroptosis activation, immune reprogramming, and microbiome modul
a day ago
- #Prostate Cancer
- #Ferroptosis
- #Traditional Chinese Medicine
- Huangqi-derived exosome-like nanoparticles (HELNs) show potential in treating prostate cancer.
- HELNs induce ferroptosis in prostate cancer cells by downregulating GPX4 protein.
- HELNs promote M1-like macrophage polarization and increase anti-tumor probiotics in the gut.
- A new nanoparticle, siGPX4@HELNs, enhances ferroptosis and improves therapeutic outcomes.
- The study uses single-cell sequencing, 16S rDNA sequencing, and bulk-RNA sequencing for analysis.