Bladder Tumor Location Matters: Trigone and Bladder Neck Involvement Predict Worse Oncological Outcomes in High-Grade Non-Muscle-Invasive Bladder Cancer - PubMed
3 hours ago
- #Tumor Location
- #Bladder Cancer
- #Oncological Outcomes
- Bladder tumor location, specifically trigone and bladder neck involvement, predicts worse oncological outcomes in high-grade non-muscle-invasive bladder cancer (NMIBC).
- A multicenter cohort of 1796 high-grade NMIBC patients treated with TURBT and BCG showed trigone/bladder neck involvement was independently associated with worse high-grade recurrence-free survival (HG-RFS) and progression-free survival (PFS).
- External validation using the SEER database (20,249 patients) confirmed trigone and bladder neck tumors had worse cancer-specific survival (CSS) compared to other locations.
- Propensity score matching (PSM) analysis reinforced these findings, showing significant HRs for HG-RFS (1.40) and PFS (1.45).
- The study highlights the need for further research on underlying mechanisms and clinical implications for treatment decisions in NMIBC with trigone/bladder neck involvement.