Dihydroartemisinin facilitates intestinal mucosal healing in inflammatory bowel disease by targeting 11βHSD-1 to reprogram macrophage metabolism - PubMed
8 hours ago
- #Inflammatory Bowel Disease
- #Macrophage Metabolism
- #Dihydroartemisinin
- Dihydroartemisinin (DHA) promotes intestinal mucosal healing in inflammatory bowel disease (IBD).
- DHA targets 11βHSD-1 to reprogram macrophage metabolism from glycolysis to oxidative phosphorylation.
- Reprogrammed macrophages secrete Relmα and Wnt3a, enhancing intestinal stem cell (ISC) proliferation and differentiation.
- The study used a DSS-induced colitis mouse model to demonstrate DHA's efficacy in mucosal healing.
- DHA's mechanism involves activating 11βHSD-1, triggering STAT3/6 signaling for metabolic remodeling.
- Findings suggest DHA could be a promising therapeutic strategy for IBD beyond its anti-inflammatory effects.