Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis - PubMed
a day ago
- #liver-fibrosis
- #gut-microbiome
- #TIMP2-pathway
- Ginseng-derived exosome-like nanovesicles (GNVs) protect against liver fibrosis in MASLD and ALD mouse models.
- GNVs reduce gut leakiness by restoring intestinal junctional proteins and rebalancing the gut microbiome.
- GNVs attenuate hepatic lipid accumulation, oxidative stress, and fibrogenic markers.
- GNVs downregulate the fibrosis-associated TIMP2 pathway in hepatic stellate cells, enhancing matrix degradation and reducing fibrogenesis.
- GNVs modulate the gut-liver axis and TIMP2 pathway to prevent gut barrier dysfunction and liver fibrosis.
- Edible GNVs represent a novel therapeutic strategy for chronic liver diseases.