PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion - PubMed
5 hours ago
- #peroxisomal quality control
- #pexophagy
- #PINK1-STUB1 pathway
- The study identifies a novel ATM-PINK1-STUB1-ABCD3-SQSTM1 signaling cascade that regulates peroxisomal selective autophagy (pexophagy) triggered by PEX13 depletion.
- PINK1 phosphorylates STUB1, increasing its E3 ligase activity to ubiquitinate ABCD3, which then recruits SQSTM1 to target peroxisomes for degradation.
- ATM activates PINK1 under peroxisomal stress, connecting cellular stress signaling to organelle quality control mechanisms.
- This pathway provides new insights into peroxisome turnover and potential therapeutic strategies for diseases involving peroxisomal dysfunction.