BDNF and GDNF in Parkinson's Disease: Associations with Clinical Features, Disease Course, and Progression-A Systematic Review - PubMed
5 days ago
- #Biomarkers
- #Parkinson's disease
- #Neurotrophic factors
- BDNF and GDNF are neurotrophic factors essential for neuronal survival and implicated in Parkinson's disease (PD).
- Reduced levels of BDNF and GDNF have been observed in PD, but their relationship with disease progression is unclear.
- A systematic review analyzed 35 studies, finding that BDNF levels decline with more severe motor symptoms but may increase in advanced PD, possibly due to levodopa treatment.
- Lower BDNF and GDNF levels are associated with cognitive decline, and BDNF is also reduced in PD patients with depression.
- Serum BDNF levels correlate with motor severity and neuropsychiatric symptoms.
- Further research is needed to clarify BDNF dynamics and GDNF's role in PD progression.