Enzymes of physiological amyloidogenesis control pathological amyloid toxicity - PubMed
3 hours ago
- #neurodegenerative diseases
- #amyloidogenesis
- #RNA enzymes
- Physiological amyloidogenesis drives the formation of functional amyloids involved in various biochemical pathways.
- RNA tailing and decay machinery controls the maturation of intracellular amyloid-like aggregates.
- Enzymes involved in physiological amyloidogenesis may also play a role in pathological amyloidogenesis linked to human proteopathies.
- Manipulating the RNA tailing-decay axis alters the toxicity of β-amyloid and α-synuclein, associated with Alzheimer's and Parkinson's diseases.
- RNA tailing enzymes TENT4b and TENT2 protect against β-amyloid- and α-synuclein-induced toxicity by promoting nontoxic amyloidogenic assemblies.
- RNA exonuclease Exosc10 increases pathological amyloid toxicity.
- Depletion of Exosc10 prevents cognitive decline and restores memory in mouse models of β-amyloid neurotoxicity.
- Pathways of physiological amyloidogenesis are implicated in pathological amyloid etiology.