Daixie recipe ameliorates diet-induced MASH in mice via activating PI3K/AKT and Keap1/Nrf2 signaling - PubMed
7 hours ago
- #MASH treatment
- #Keap1/Nrf2 pathway
- #PI3K/AKT signaling
- Daixie recipe (DXR) effectively treats metabolic dysfunction-associated steatohepatitis (MASH) in mouse models.
- DXR reduces hepatic steatosis, inflammation, and oxidative stress by activating PI3K/AKT and Keap1/Nrf2 signaling pathways.
- Key active ingredients are flavonoids, including apigenin and quercetin, which promote AKT1 phosphorylation and Nrf2 activation.
- DXR downregulates lipid synthesis enzymes (e.g., FASN, SCD1, ACC1) and upregulates CPT1a, reducing hepatocyte apoptosis.
- The recipe lowers serum biomarkers (ALT, AST, TG, TC, LDL-c) and inflammatory cytokines (TNF-α, IL-1β, IL-6).