YY1 Interacts with Promoter R-Loops to Regulate Transcription - PubMed
12 hours ago
- #YY1
- #R-loops
- #transcription regulation
- R-loops are crucial for gene regulation and genome stability.
- APEX-based proximity labeling was used to profile the R-loop proximal proteome.
- YY1 was identified as an R-loop-binding protein through proteomic data and bioinformatic predictions.
- CRISPR-dCas9/gRNA targeting system induced localized R-loops, increasing YY1 occupancy at specific loci.
- ChIP-seq and RNA-seq analyses showed YY1-R-loop interactions at promoters regulate transcription.
- YY1 is a novel R-loop interaction protein that modulates gene expression.