Postsynaptic Induction and Presynaptic Expression of Long-Term Potentiation at Excitatory Synapses on Layer 2/3 VIP Interneurons in the Somatosensory Cortex - PubMed
7 hours ago
- #VIP interneurons
- #long-term potentiation
- #synaptic plasticity
- Study focuses on long-term potentiation (LTP) at excitatory synapses on layer 2/3 VIP interneurons (VIP-INs) in the mouse somatosensory cortex.
- LTP induction involves postsynaptic depolarization and is enhanced by GABAaR inhibition blockade.
- LTP in VIP-INs depends on mGluR-1 and L-type VGCCs, not NMDARs or mGluR-5, acting via G-protein-coupled pathways and Src-family kinases.
- Presynaptic expression of LTP is indicated by paired-pulse ratio (PPR) and coefficient of variation (CV) analyses.
- Retrograde signaling through endocannabinoids (eCBs), not BDNF, is crucial for presynaptic LTP expression.
- LTP at VIP-INs may enhance disinhibition of excitatory neurons during learning by inhibiting SST-INs.