Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS - PubMed
3 hours ago
- #Retinal Atrophy
- #Neuroinflammatory Disorders
- #Optic Neuritis
- Study examines GCL and IPL thinning in optic neuritis (ON) associated with NMOSD, MOGAD, and MS, beyond composite GCIPL measurements.
- AQP4-ON and MOGAD-ON show more severe GCL and IPL thinning compared to MS-ON, with similar patterns between the former two.
- The GCL/GCIPL ratio is lower in ON eyes than healthy controls, correlating with GCIPL volume loss and more pronounced in AQP4-ON and MOGAD-ON.
- Longitudinal data reveal early reduction in GCL/GCIPL ratio within a month of acute ON onset, linked to greater GCIPL atrophy.
- Findings suggest GCL thins more than IPL after ON, with consistent patterns across MS, MOGAD, and NMOSD, informing retinal atrophy dynamics.