Hepatocyte TIA1 constrains metabolic steatohepatitis by translationally suppressing Srebf1 mRNA in stress granules - PubMed
6 hours ago
- #lipogenesis
- #MASLD
- #stress granules
- Hepatocyte TIA1 inhibits metabolic steatohepatitis by translationally suppressing Srebf1 mRNA in stress granules.
- TIA1 deletion exacerbates dietary-induced steatosis, inflammation, and fibrosis in MASLD/MASH models.
- TIA1 binds the 3' UTR of Srebf1 mRNA, sequesters it in stress granules, and represses SREBP1 translation.
- Inhibition of SREBP1 rescues metabolic perturbations caused by TIA1 ablation, confirming the mechanistic pathway.
- The TIA1-SGs-SREBP1 axis is identified as a hepatoprotective factor and potential therapeutic target.