The relationship between gut microbiota and neurodegenerative diseases: a genetic and epigenetic perspective - PubMed
4 hours ago
- #gut-brain axis
- #neurodegenerative diseases
- #gut microbiota
- Gut microbiota (GM) affects human health beyond the gastrointestinal tract, influencing immune and endocrine systems.
- Microbiota-derived metabolites can alter gene expression, contributing to neurological diseases.
- The gut-brain axis (GBA) plays a role in neurodegenerative diseases (NDs) like Alzheimer's, Parkinson's, Huntington's, and Multiple Sclerosis.
- Systems such as short-chain fatty acids (SCFA), the vagus nerve, inflammatory responses, and intestinal permeability are involved in NDs pathogenesis.
- Changes in microbiota can lead to neuroinflammation and cognitive impairment.
- Treatment strategies include probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), and nutritional interventions.
- Personalized approaches are needed due to individual variations in microbiota structure.