Iron deficiency induces maturation-dependent loss of pancreatic β-cells - PubMed
6 days ago
- #Iron deficiency
- #Diabetes research
- #Pancreatic β-cells
- Iron deficiency affects pancreatic β-cells differently based on their maturation stage.
- Immature β-cells require iron for metabolic transition to functional maturity; iron restriction impairs oxidative metabolism and survival.
- Mature β-cells are resilient to iron depletion, indicating a developmental switch in iron dependency.
- Iron is identified as a key metabolic cue in β-cell development.
- Findings suggest strategies for generating functional stem cell-derived β-cells for diabetes therapy.