Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility - PubMed
12 hours ago
- #microbiome
- #colonocytes
- #nicotinic acid
- The gut microbiome influences the regional identity of colonocytes along the colon's length.
- Microbiome-produced nicotinic acid induces Pparα expression, establishing proximal colonocyte identity.
- Microbiome-driven proximal identity provides protection against tissue injury in mice.
- Human colon regionalization is affected during certain disease states, leading to loss of proximal identity.