Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer - PubMed
7 hours ago
- #breast cancer
- #lung metastasis
- #palmitoylation
- Palmitoylation regulates KAT2A expression in breast cancer lung metastases.
- DHHC20 palmitoylates TM4SF1, promoting its plasma membrane localization.
- Phosphorylation of STAT3, a transcriptional regulator of KAT2A, is fostered by TM4SF1.
- Silencing Zdhhc20 and Tm4sf1 or expressing a Tm4sf1 mutant reduces lung metastasis growth, which is rescued by Kat2a expression.
- Evidence of palmitoylation-induced KAT2A regulation is found in breast cancer patient lung metastasis samples.