Natural triterpenoid Ardisiacrispin B attenuates colitis-associated cancer via JAK2/STAT3 pathway and gut microbiota modulation - PubMed
a day ago
- #Colitis-associated cancer
- #Ardisiacrispin B
- #Gut microbiota
- Ardisiacrispin B (AB) attenuates colitis-associated cancer (CAC) by modulating the JAK2/STAT3 pathway and gut microbiota.
- AB reduces disease severity in CAC mouse models, including symptoms like weight loss, diarrhea, and rectal bleeding.
- Histopathological improvements include preserved mucosal architecture and reduced tumor size and number.
- AB modulates gut microbiota, enriching beneficial taxa and reducing inflammation-associated bacteria.
- It downregulates pro-inflammatory cytokines and chemokines, enhancing apoptotic signaling in colonic epithelial cells.
- Mechanistically, AB inhibits key pathways like IL-6/JAK2/STAT3, LPS/TLR4/MyD88/NF-κB, and MAPK cascades.
- The study highlights AB's potential as a preventive and therapeutic agent for CAC.