Single-cell-resolution fate mapping reveals embryonic venous origins of fenestrated hindbrain choroid plexus vasculature - PubMed
a day ago
- #vascular development
- #choroid plexus
- #single-cell fate mapping
- Single-cell-resolution fate mapping identifies two venous sources for hindbrain choroid plexus (mCP) vasculature in zebrafish.
- Venous marker flt4 is highly and persistently expressed in these endothelial cell (EC) lineages, supporting their venous identity.
- These venous origins also contribute ECs to other cranial vessels, including those that later acquire blood-brain barrier (BBB) characteristics.
- Flt4 and Vegfr2 signaling are co-required for mCP vascularization, with PI3K and ERK pathways playing necessary roles.
- Flt4 signaling helps in the angiogenic separation of CP and BBB-associated capillaries from shared embryonic domains.
- The study provides insights into the developmental mechanisms of choroid plexus vascularization and heterogeneous cerebrovascular development.