Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling - PubMed
3 hours ago
- #Pancreatic Cancer
- #Gangliosides
- #Neural Crosstalk
- Neural networks are a crucial but underexplored part of the pancreatic tumor microenvironment.
- Acinar-to-ductal metaplasia (ADM) and neural remodeling interact reciprocally during pancreatic ductal adenocarcinoma (PDAC) initiation and progression.
- Inflammation and Kras mutation induce ADM in the pancreas.
- Metaplastic epithelial cells promote neuritogenesis, while neural remodeling affects ADM formation.
- Ganglioside metabolites, particularly GM3, mediate bidirectional crosstalk between neural and epithelial cells.
- B4GALT5 is overexpressed in ADM, PanIN, and PDAC lesions and plays a key role in disease progression.
- Pharmacological inhibition of B4GALT5 reduces neuronal growth and reverses ADM formation and progression.
- Neuronal-ADM interactions and glycosphingolipid metabolism are potential therapeutic targets for early PDAC intervention.