The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review - PubMed
3 hours ago
- #PCOS
- #vitamin D
- #systematic review
- Vitamin D deficiency is common in women with PCOS and is linked to adverse metabolic and reproductive outcomes.
- Observational studies found inverse associations between serum vitamin D levels and insulin resistance, BMI, and leptin, but not with total testosterone.
- RCTs showed modest and inconsistent improvements in insulin sensitivity, especially in vitamin D-deficient women.
- Reproductive benefits like cycle regularity or ovulation were observed only in some trials with small samples and short follow-up.
- Vitamin D supplementation may complement existing treatments but is not recommended as a stand-alone therapy for PCOS.
- Evidence is insufficient to support routine vitamin D supplementation for fertility outcomes in PCOS.