CD4+ T cell-mediated immunity protects from VSV-SUD lethal challenge in a mouse model of Sudan virus infection - PubMed
3 hours ago
- #CD4+ T cells
- #Vaccine immunity
- #Sudan virus
- CD4+ T cell-mediated immunity, rather than virus-neutralizing antibodies, protects against lethal Sudan virus challenge in a mouse model.
- Vaccination with a live-attenuated YF17D vector expressing Sudan virus glycoprotein induced protection, with Fcγ receptor effector mechanisms not essential for survival.
- Interferon-γ (IFNγ)-secreting CD4+ T cells, including short-lived effector cells and regulatory T cells, were identified as key players for protection.
- Proliferative antigen-specific CD4+ T cells and sustained IFNγ production, orchestrating an acute antiviral response, appear required for protection against Sudan virus.