Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability - PubMed
6 days ago
- #epigenomics
- #renal cell carcinoma
- #cancer progression
- Comprehensive epigenomic atlas generated for clear cell renal cell carcinoma (ccRCC) using 194 datasets from 57 human tissue samples.
- Significant reprogramming of enhancer and HIF2α cistromes observed during normal-to-tumor transition, with minimal differences between localized and metastatic tumors.
- Reactivation of kidney-specific developmental pathways identified as a driver of malignancy in ccRCC.
- Cistrome-wide association study validated five known RCC risk loci and identified six novel loci, including a functionally validated locus at 12q24 linked to SCARB1.
- Datasets provide insights into developmental pathways in ccRCC tumorigenesis, epigenetic mechanisms of heritability, and a resource for the research community.