Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease - PubMed
2 hours ago
- #Alzheimer's disease
- #GBF1 protein
- #Amyloid pathology
- The intracellular protein GBF1 is linked to amyloid pathology in Alzheimer's disease.
- GBF1 regulates protein trafficking and its variants are associated with neurological conditions.
- Neuropathological alterations in GBF1 were observed in human brains and 5XFAD mouse models.
- Genetic analysis identified suggestive variants of GBF1 associated with Alzheimer's disease.
- Downregulation of GBF1 retards amyloid precursor protein maturation and reduces Aβ levels.
- GBF1 may contribute to Alzheimer's disease by affecting amyloid deposition and Aβ levels.