Circulating cardiometabolic metabolite profiles associated with ambient air pollution and atrial fibrillation risk: a prospective cohort study - PubMed
3 hours ago
- #Atrial fibrillation
- #Air pollution
- #Metabolomics
- Study links ambient air pollution to atrial fibrillation (AF) risk through metabolic mechanisms.
- Analyzed 227,324 UK Biobank participants, identifying a 65-metabolite signature associated with air pollution.
- Metabolic signature includes lipoprotein lipids, subclasses, fatty acids, and amino acids.
- Each standard deviation increase in metabolic signature linked to 18% higher AF risk.
- Metabolic profile mediates 15.45% of the air pollution-AF relationship, with lipoproteins showing strongest mediation.
- Findings provide insights into biological mechanisms connecting environmental exposures to AF.