DksA inhibitors against intracellular and persistent Salmonella are effective in acute models of infection - PubMed
3 hours ago
- #Antibiotics
- #Salmonella
- #DksA inhibitors
- DksA protein regulates genes involved in metabolism, translation, and virulence in Gram-negative bacteria.
- A conserved acidic pocket in DksA's coiled-coil domain is identified as a drug target.
- N-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamide is identified as a DksA inhibitor with moderate antimicrobial activity.
- Derivatization of the compound improved its IC50 values and antimicrobial activity against Salmonella and other Gram-negative bacteria.
- N-(4-phenylbutyl)-1H-1,2,4-triazole-3-carboxamide analog shows good pharmacokinetic properties and protects mice against Salmonella infections.
- The study identifies a new class of antibiotics targeting DksA, effective against Gram-negative pathogens.