Obesity and Cancer: A Translational Science Review - PubMed
4 days ago
- #obesity
- #cancer
- #inflammation
- Obesity is linked to increased risk of several cancers, including endometrial, breast, and liver cancers.
- Overweight and obesity contribute to about 10% of new cancer diagnoses annually in the US, with higher rates for certain cancers like endometrial cancer.
- Adipose tissue dysfunction in obesity leads to inflammation, altered hormone levels, and oxidative stress, promoting cancer development.
- Obesity-associated inflammation involves elevated cytokines and prostaglandins, which can stimulate tumor growth and suppress immune responses.
- Gut microbiome changes in obesity, such as reduced Akkermansia muciniphila, may further contribute to cancer risk.
- Weight loss, especially more than 10%, may reduce cancer risk by mitigating obesity-related metabolic and inflammatory effects.