Flavonoids of Ziziphora clinopodioides improve Alzheimer's cognitive impairment and inhibit NLRP3 inflammasome activation via autophagy-lysosome pathway - PubMed
3 hours ago
- #Alzheimer's disease
- #NLRP3 inflammasome
- #Autophagy-lysosome pathway
- Flavonoids from Ziziphora clinopodioides (ZCF) improve cognitive impairment in Alzheimer's disease (AD) models.
- ZCF and its main component, linarin, reduce Aβ deposition and Tau phosphorylation in 3 × Tg-AD mice.
- ZCF suppresses NLRP3 inflammasome activation by enhancing the autophagy-lysosome pathway.
- Mechanistically, ZCF promotes NLRP3 degradation via autophagy without affecting its mRNA levels.
- ZCF and linarin show potential as therapeutic candidates for AD treatment.