Translating a miRNA Signal into Physical Immunomodulation via Programmed DNA Network Assembly on Mitochondria - PubMed
3 hours ago
- #immunotherapy
- #precision medicine
- #DNA nanotechnology
- Precision immunotherapy is limited by nonspecific toxicity of cGAS-STING pathway agonists.
- A programmable DNA nanomaterial acts as a logic-gated theranostic agent targeting mitochondria.
- The nanodevice detects oncogenic microRNA-21 (miR-21) and triggers assembly of a disruptive DNA network on mitochondria.
- Mitochondrial membrane damage releases tumor cell's mitochondrial DNA, activating a localized STING-mediated immune response.
- The approach enables diagnostic imaging and suppresses primary and metastatic tumors without systemic toxicity.
- This work introduces a new paradigm: converting molecular signals into physical immunomodulatory structures.