Machine Learning Integrates Bulk and Single-Nucleus RNA Sequence to Explore Apoptosis-Related Gene in Myocardial Infarction - PubMed
5 hours ago
- #Myocardial Infarction
- #Apoptosis
- #TNFRSF12A
- Myocardial infarction (MI) is a leading cause of cardiovascular death, with apoptosis playing a key role in adverse cardiac remodeling.
- The study integrates single-nucleus RNA-seq (snRNA-seq) and bulk RNA-seq to explore apoptosis-related genes (ARGs) in MI.
- Fibroblasts show significantly elevated apoptotic activity post-MI compared to other cell types.
- TNFRSF12A is identified as a major regulator of ARGs activation in MI through multiomics analysis.
- Experimental validation confirms upregulation of TNFRSF12A in MI models and TGF-β induced NIH3T3 cells.
- TNFRSF12A is proposed as a potential diagnostic biomarker and therapeutic target for MI.