Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity - PubMed
3 hours ago
- #dendritic cells
- #cancer immunotherapy
- #mitochondrial metabolism
- Intratumoral conventional type 1 dendritic cells (cDC1s) have distinct mitochondrial states that influence their antitumor immunity.
- OPA1-mediated mitochondrial energy and redox metabolism drives cDC1s' antigen presentation and CD8+ T cell priming functions via NRF1 expression and electron transport chain integrity.
- During tumor progression, cDC1s experience declines in mitochondrial membrane potential, volume, and OPA1-NRF1 signaling, reducing their effectiveness.
- Administering cDC1s with polarized mitochondria into tumors provides immunotherapeutic benefits, especially when combined with immune checkpoint blockade.
- Targeting mitochondrial metabolism and signaling may enhance cDC1 function for improved cancer immunotherapy outcomes.