One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development - PubMed
7 hours ago
- #mRNA vaccine
- #Janus dendrimer
- #delivery system
- Development of a one-component ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA vaccines.
- Simplifies synthesis and reduces complexity compared to four-component lipid nanoparticles.
- Efficiently delivers mRNA to spleen and lymph nodes, demonstrated with a norovirus capsid protein mRNA vaccine.
- Enables rapid global distribution of mRNA vaccines during pandemics.
- Addresses challenges like stability, availability, durability, and adverse effects in current delivery systems.