FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression - PubMed
4 hours ago
- #FUT8
- #glycolysis
- #ccRCC
- FUT8 reprograms glycolytic metabolism in clear cell renal cell carcinoma (ccRCC).
- FUT8 enhances HIF-1α-driven glycolysis, increasing lactate production and promoting pan-lysine lactylation (pan-Kla).
- FUT8 promotes PKM2 K115 lactylation, boosting its enzymatic activity and reducing nuclear localization.
- This mechanism drives epithelial-mesenchymal transition and malignant progression in ccRCC.
- FUT8 is identified as a promising therapeutic target for ccRCC.