Nucleolin (NCL) is essential for hair cell stereocilia maintenance and auditory function in mice - PubMed
4 hours ago
- #RNA-binding proteins
- #Stereocilia
- #Hearing
- Nucleolin (NCL) is crucial for maintaining stereocilia in inner ear hair cells in mice.
- NCL knockout causes progressive stereocilia degeneration in outer hair cells (basal-to-apical) and fusion in inner hair cells (apical-to-basal).
- Deficits in stereocilia due to NCL knockout lead to hair cell loss and hearing impairment.
- RNA-seq analysis reveals NCL affects mRNA levels of genes like Espnl and Ptprq, important for stereocilia development/maintenance.
- NCL binds to and stabilizes Espnl and Ptprq mRNAs, indicating its regulatory role in stereocilia maintenance.