Microneedle-Based Codelivery of Platycladus orientalis-Derived Extracellular Vesicles and Minoxidil Nanoparticles for Androgenetic Alopecia Treatment - PubMed
19 hours ago
- #androgenetic-alopecia
- #microneedles
- #extracellular-vesicles
- A fast-dissolving microneedle patch using chondroitin sulfate and carboxymethyl chitosan co-delivers Platycladus orientalis extracellular vesicles (PO-EVs) and minoxidil nanoparticles for androgenetic alopecia treatment.
- PO-EVs have antioxidant, anti-inflammatory, and pro-angiogenic properties, while MXD NPs improve minoxidil's solubility and retention at the hair follicle site.
- In a mouse model, this dual-loaded microneedle system promoted hair regrowth by activating stem cells, reducing oxidative stress and inflammation, and increasing follicular microvessel density without significant skin irritation or systemic toxicity.