High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure - PubMed
8 hours ago
- #neuropathology
- #c-hGH contamination
- #iatrogenic Alzheimer disease
- Iatrogenic Alzheimer disease (iAD) is described in recipients of cadaveric pituitary-derived human growth hormone (c-hGH) contaminated with amyloid-β (Aβ) seeds.
- A case series of four male c-hGH recipients developed dementia with prominent language involvement, with symptom onset between ages 47 and 60.
- Postmortem examination of one patient (age 57) showed severe tauopathy and neuropathological features of Alzheimer disease.
- Findings suggest iAD can have histopathological features similar to sporadic Alzheimer disease, with language impairment as a potential phenotypic marker.