Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice - PubMed
4 hours ago
- #GHSR-1a
- #sarcopenia
- #mitophagy
- Ghrelin receptor (GHSR-1a) deletion improved muscle fatigue resistance, endurance, and strength in aging male mice without affecting muscle mass or longevity.
- Mitochondrial function markers like PGC-1α and mitophagy signals (PINK1/p62) were enhanced in old mice with GHSR deletion, linking improvements to mitochondrial health.
- Pharmacological inhibition of GHSR-1a with PF-5190457 replicated the benefits on endurance and mitochondrial markers (e.g., PGC-1α, LC3II, Bnip3), while also reducing body weight and adiposity.
- Proteomics analysis highlighted mitochondrial components as crucial for maintaining muscle mass and function during aging.
- The findings suggest GHSR-1a is a promising therapeutic target for treating age-related sarcopenia, with potential pharmacological applications.