Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1 - PubMed
3 hours ago
- #TNF-α
- #MINDY2
- #RIPK1
- MINDY2, a deubiquitinating enzyme, inhibits TNF-α-induced cell death by targeting RIPK1.
- MINDY2 modulates ubiquitination at the K612 site of RIPK1, affecting TNFR1 recruitment and complex 1 signaling.
- MINDY2-deficient mice show increased hypothermia, mortality, and intestinal damage after TNF-α challenge compared to wild-type mice.
- The study identifies MINDY2 as a checkpoint in RIPK1-dependent cell death, with deficiency exacerbating TNF-mediated tissue damage in vivo.