Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal c
4 days ago
- #Cannabidiol
- #Chronic stress
- #Antidepressant
- CBD reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice.
- CBD (30 mg/kg) induced behavioral improvement within 7 days, faster than escitalopram (14 days).
- Low dose CBD (7.5 mg/kg) potentiated the anti-stress effects of escitalopram in mice under chronic stress.
- NAPE-PLD in the prefrontal cortex (PFC) is involved in the anti-stress effects of CBD + escitalopram.
- CBD + escitalopram restored CUS-induced decreased NAPE-PLD expression in the PFC.
- Behavioral effects of CBD + escitalopram were absent in NAPE-PLD knockout mice or PFC-specific NAPE-PLD deletion.
- CBD + escitalopram facilitated NAPE-PLD expression in parvalbumin (PV) interneurons in the PFC.
- CBD may optimize SSRI-antidepressant action by restoring PFC inhibitory/excitatory balance via NAPE-PLD signaling.