M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors - PubMed
5 days ago
- #pediatric brain tumors
- #liquid biopsy
- #DNA methylation
- M-PACT uses cell-free DNA methylomes for pediatric brain tumor classification.
- Achieves 92% accuracy in embryonal CNS tumor benchmarking (n=79) and 88% in validation (n=58).
- Works with nonembryonal CNS tumors, balanced tumor genomes, and nonmalignant CSF.
- Enables methylation-based cellular deconvolution and copy-number variation detection.
- Provides a blueprint for CNS tumor classification from low-input cfDNA methylomes.