GPR54 regulates non-small cell lung cancer development via dopa decarboxylase - PubMed
4 hours ago
- #GPR54
- #Dopa decarboxylase
- #Non-small cell lung cancer
- GPR54 regulates non-small cell lung cancer (NSCLC) development via dopa decarboxylase (DDC).
- GPR54 deletion or knockdown induces apoptotic cell death in NSCLC cells.
- GPR54 influences NSCLC proliferation through Gαq/11/AKT and β-arrestin/ERK signaling pathways.
- GPR54 deletion alters glycolysis-related genes and regulates DDC expression.
- DDC regulates NF-κB phosphorylation, impacting NSCLC cell proliferation and tumor growth.
- GPR54 may serve as a diagnostic marker and therapeutic target for NSCLC.