Adverse Pregnancy Outcomes and Prevalence Associated With Arboviral Infections (Zika, Dengue, and Chikungunya): An Umbrella Review of Systematic Reviews and Meta-Analyses - PubMed
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- #dengue virus
- #Zika virus
- #chikungunya virus
- Maternal infection with Zika virus (ZIKV), dengue virus (DENV), or chikungunya virus (CHIKV) may increase the risk of adverse pregnancy and foetal outcomes.
- High credibility evidence links maternal ZIKV infection to microcephaly and corpus callosum anomalies.
- Moderate credibility evidence supports ZIKV associations with decreased brain volume, ventriculomegaly, and other neuroimaging abnormalities.
- DENV shows moderate associations with preterm birth, low birth weight, miscarriage, stillbirth, and postpartum haemorrhage.
- CHIKV evidence remains limited at the meta-analytic level despite emerging primary data.
- Improved methodological rigour and surveillance are needed to protect maternal and child health.