GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma - PubMed
3 hours ago
- #immunotherapy
- #GSDME
- #pyroptosis
- GSDME-mediated pyroptosis impacts the immunosuppressive microenvironment in lung adenocarcinoma (LUAD).
- A pyroptosis-related prognostic model (PYR_score) was developed using machine learning, showing high efficacy in predicting LUAD prognosis.
- Higher PYR_score values correlate with shorter progression-free and overall survival.
- CHX and TNF-α induce GSDME-mediated pyroptosis, leading to elevated HMGB1 levels.
- Increased HMGB1 is associated with worse efficacy of immune checkpoint inhibitors in LUAD patients.
- HMGB1 enhances the proliferative ability and IL-8 secretion of Treg cells in vitro.
- Caspase-3 and IL-8 inhibitors slow tumor growth in LLC-bearing mice.
- IL-8 inhibitors may enhance the effectiveness of anti-PD-1 immunotherapy.
- GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment via HMGB1, Treg cells, and MDSCs.
- Further clinical validation is needed for therapeutic interventions targeting these pathways.