Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy - PubMed
a day ago
- #acne-therapy
- #microneedles
- #nanoparticles
- Dissolvable silk microneedles (Mino@ZIF-8/SF MNs) deliver minocycline-loaded ZIF-8 nanoparticles for targeted acne therapy.
- Mino@ZIF-8/SF MNs exhibit rapid dissolution (<1 min), high drug loading (≥40.11%), and pH-responsive release (faster at pH 5.5).
- The microneedles achieve >95% inhibition of Cutibacterium acnes and reduce inflammatory responses in sebocytes.
- RNA-sequencing suggests sebocyte metabolic reprogramming, including enhanced apoptosis and modulated lipid metabolism.
- In a mouse model, Mino@ZIF-8/SF MNs accelerated lesion resolution, reduced inflammation, and showed no systemic toxicity.
- The platform combines antibacterial, anti-inflammatory, and metabolic reprogramming for precise acne therapy.