Wenyang Decoction Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization and the PI3K/AKT/mTOR/HIF-1α Signaling Pathway - PubMed
2 days ago
- #macrophage polarization
- #ulcerative colitis
- #PI3K/AKT/mTOR
- Wenyang Decoction (WYD) shows therapeutic effects in DSS-induced ulcerative colitis (UC) by regulating macrophage polarization.
- WYD treatment reduces disease activity index (DAI), restores colon length, and improves mucosal integrity in UC mice.
- WYD suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and enhances antioxidant enzyme activities (SOD, CAT).
- Mechanistically, WYD inhibits M1 macrophage polarization and promotes M2 polarization.
- WYD modulates the PI3K/AKT/mTOR/HIF-1α signaling pathway, both in vivo and in vitro.
- The study suggests WYD as a potential therapeutic strategy for UC.