Restoring mitochondrial lipid homeostasis with arachidonic acid supplementation to alleviate cognitive impairment in schizophrenia patients - PubMed
3 hours ago
- #mitochondrial dysfunction
- #cognitive impairment
- #schizophrenia
- Mitochondrial dysfunction is implicated in schizophrenia, but lipid dysregulation's role is not fully understood.
- Study involved 93 schizophrenia patients and 34 healthy controls, analyzing mitochondrial lipid profiles with advanced techniques.
- Arachidonic acid (AA) deficiency was identified in schizophrenia patients, correlating with cognitive impairment.
- Six-week AA supplementation improved cognitive functions like reaction speed, memory accuracy, and decision-making.
- AA supplementation restored mitochondrial lipid homeostasis by reducing oxidative lipids and affecting mitophagy and ferroptosis pathways.
- Findings suggest mitochondrial lipid modulation as a potential therapeutic strategy for schizophrenia.